Session Details

Workshop 5 - Engineering to Control Cell Environment during Processing
Saturday, September 14, 2019 01:45 PM - 03:15 PM
Plenary Hall
Cells don't like being outside the body. In cell therapy we are working with primary cells that are engineered for therapeutic efficacy but not to tolerate a production environment. How do we tailor our systems - by biological and physical engineering - to make the most of the delicate, precious, short-lived cells that become the vehicle for saving lives?

Chair: Erika Trauzzi, Berkeley Lights Inc., USA

Designing cell therapies to work effectively in immunosuppressive tumor microenvironment
James Lim, PhD, Xcell Biosciences Inc., USA
Learning objectives:
•      Key features of the immunosuppressive tumor microenvironment
•      In vitro modeling of tumor microenvironment through pressure, oxygen and pH regulation
•      Manufacturing cell therapies under high pressure and low oxygen to improve clinical outcomes for solid

Synthetic activation for efficient expansion of antigen specific T Cells
Peter Beemiller Berkeley Lights Inc., USA
Learning objectives:
•      Introduce attendees to BLI's solutions for expanding rare, antigen specific T Cells
•      Introduce BLI's work on screening peptides for immunogenicity
•      Introduce BLI's microfluidic platform for assessing T Cell functional profiles

Engineering Hematopoietic Stem Cells - An Academic Perspective
Angelo Cardoso, MD, PhD, Beckman Research Institute, City of Hope, USA
Learning objectives:
•      From bench to manufacturing to Phase I trial of genome-edited HSPC
•      Second generation engineering and manufacturing of gene-modified HSPC
•      Preserving stemness of engineered HSPC products