Session Details

Hot Topic Session 1 - Bioengineering of the GI Tract
Thursday, May 30, 2019 07:30 AM - 08:30 AM
Room 212
Chair: Rachele Ciccocioppo, MD, University of Verona School of Medicine, Italy

Speakers:
Advanced Stem Cell Enteric Neuropathy Therapy: Tissue-Engineering the Second Brain
Tracy Grikscheit, MD, Children's Hospital of Los Angeles, United States

The enteric nervous system (ENS) includes wide-ranging cell types in a diverse interconnected network with intimate connectivity and approximately as many neurons as the spinal cord.  For this reason it is often termed the second brain.  Cells in the ENS arise from vagally specified enteric neural crest cells, which can also be differentiated from human pluripotent stem cells (hPSC).   Progress toward meeting the regulatory conditions for hPSC as cell therapies has been advanced by the generation of clinically acceptable good manufacturing practice compliant lines, which include appropriate donor consenting, extensive documentation of clinically acceptable reagents, and further safety testing.  initial cell therapy in development in our lab of Advanced Stem Cell Enteric Neuropathy Therapy, or ASCENT, might be of use in the future human therapy of enteric neuropathies.

Regenerative Medicine Technologies Technologies Applied to Beta Cell Replacement
Giuseppe Orlando, MD, PhD, Wake Forest University Baptist Medical Center, USA

Learning Objectives:  
• To illustrate the state of the art of beta cell replacement therapies for the treatment of type 1 diabetes
• To explain how regenerative medicine technologies may impact the field of beta cell replacement